The effects of prenatal alcohol exposure on the developmental retina of mice.

نویسندگان

  • Jie-Xin Deng
  • Xi Liu
  • Jian-Feng Zang
  • Hong-En Huang
  • Yan Xi
  • Hong Zheng
  • Huan-Ling Yao
  • Dong-Ming Yu
  • Jin-Bo Deng
چکیده

AIMS Our aim is to investigate the effects of prenatal alcohol exposure (PAE) on the development of retinal bipolar and horizontal cells. METHODS The alterations of the retinal bipolar and horizontal cells in P7, P14 and P30 mice were observed after PAE, with immunofluorescent labeling and DiI diolistic assay. RESULTS The retinal development of filial pups was affected by PAE in a dose-dependent and long-term manner. The number of bipolar cells of alcohol groups was significantly lower than that of the control, and the dendritic receptive field of horizontal cells was also significantly smaller than those of the control groups (P < 0.01). CONCLUSION PAE was able to cause retarded development of pup retinal neural cells.

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عنوان ژورنال:
  • Alcohol and alcoholism

دوره 47 4  شماره 

صفحات  -

تاریخ انتشار 2012